An intra-bacterial activity for a T3SS effector
نویسندگان
چکیده
منابع مشابه
Proteasome activity imaging and profiling characterizes bacterial effector syringolin A.
Syringolin A (SylA) is a nonribosomal cyclic peptide produced by the bacterial pathogen Pseudomonas syringae pv syringae that can inhibit the eukaryotic proteasome. The proteasome is a multisubunit proteolytic complex that resides in the nucleus and cytoplasm and contains three subunits with different catalytic activities: β1, β2, and β5. Here, we studied how SylA targets the plant proteasome i...
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Effector molecules translocated by the Salmonella pathogenicity island (SPI)1-encoded type 3 secretion system (T3SS) critically contribute to the pathogenesis of human Salmonella infection. They facilitate internalization by non-phagocytic enterocytes rendering the intestinal epithelium an entry site for infection. Their function in vivo has remained ill-defined due to the lack of a suitable an...
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10 Central to the pathogenesis of many bacterial pathogens is the ability to deliver effector 11 proteins directly into the cells of their eukaryotic host. EspF is one of many effector proteins 12 exclusive to the attaching and effacing pathogen family that includes enteropathogenic 13 (EPEC) and enterohemorrhagic E. coli (EHEC). Work in recent years has revealed EspF to be 14 one of the most m...
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چکیده ندارد.
15 صفحه اولT3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus
The production of antimicrobial reactive oxygen species by the nicotinamide dinucleotide phosphate (NADPH) oxidase complex is an important mechanism for control of invading pathogens. Herein, we show that the gastrointestinal pathogen Vibrio parahaemolyticus counteracts reactive oxygen species (ROS) production using the Type III Secretion System 2 (T3SS2) effector VopL. In the absence of VopL, ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-58062-y